In one study taking Tulsi for one month caused a significant reduction in fasting blood sugar, uronic acid, total amino acids, total cholesterol, triglyceride, phospholipids and total lipids (6). It is a broad spectrum antimicrobial (contains eugenol which is also an antimicrobial that exists in cloves), acts as an immunostimulant, reduces uric acid levels (has been used in kidney stone treatment), and acts as a mood stabilizer (normalizes neurotransmitter levels) (7, 8, 9, 10). Tulsi has Cox 2 inhibiting properties and thus is a potent anti-inflammatory agent (11). It also works to reduce edema and has anti-arthritic properties (12).
It has been used as part of a cancer treatment protocol as it discourages new blood vessel growth to tumors, as well as protects healthy cells from side effects of chemotherapy and radiation (13, 14). It has also been shown to be hepatoprotective for various chemicals including acetaminophen and is a potent antioxidant having been shown to increase SOD and glutathione levels if needed (15, 16, 17).
We evaluate Tulsi on all patients but find it most useful when patients have a stressful lifestyle and need adrenal support, though it is also part of our antimicrobial armamentarium.
Because of its strong adrenal restorative properties, depending on genetics, some people only need a very small dose, 1 cap daily, while others may need up to 4 daily (one cap 4x/day). You may want to start low and increase as needed.
It has no known side effects but, as with most herbs, caution is advised during pregnancy. It may be contraindicated in people with severe hypoglycemia or those on blood thinning medications.
1. Samson, J., Sheeladevi, R., & Ravindran, R. (2007). Oxidative stress in brain and antioxidant activity of Ocimum sanctum in noise exposure. Neurotoxicology, 28(3), 679-685.
2. Sen, P., Maiti, P. C., Puri, S., Ray, A., Audulov, N. A., & Valdman, A. V. (1992). Mechanism of anti-stress activity of Ocimum sanctum Linn, eugenol and Tinospora malabarica in experimental animals. Indian journal of experimental biology, 30(7), 592-596.
3. Sood, S., Narang, D., Thomas, M. K., Gupta, Y. K., & Maulik, S. K. (2006). Effect of Ocimum sanctum Linn. on cardiac changes in rats subjected to chronic restraint stress. Journal of ethnopharmacology, 108(3), 423-427.
4. Gholap, S., & Kar, A. (2004). Hypoglycaemic effects of some plant extracts are possibly mediated through inhibition in corticosteroid concentration. Die Pharmazie-An International Journal of Pharmaceutical Sciences, 59(11), 876-878.
5. Tabassum, I., Siddiqui, Z. N., & Rizvi, S. J. (2010). Effects of Ocimum sanctum and Camellia sinensis on stress-induced anxiety and depression in male albino Rattus norvegicus. Indian journal of pharmacology, 42(5), 283.
6. Rai, V., Iyer, U., & Mani, U. V. (1997). Effect of Tulasi (Ocimum sanctum) leaf powder supplementation on blood sugar levels, serum lipids and tissues lipids in diabetic rats. Plant foods for human nutrition, 50(1), 9-16.
7. Prakash, P., & Gupta, N. (2005). Therapeutic uses of Ocimum sanctum Linn (Tulsi) with a note on eugenol and its pharmacological actions: a short review. Indian journal of physiology and pharmacology, 49(2), 125.
8. Godhwani, S., Godhwani, J. L., & Was, D. S. (1988). Ocimum sanctuma preliminary study evaluating its immunoregulatory profile in albino rats. Journal of ethnopharmacology, 24(2), 193-198.
9. Sarkar A, Pandey DN, Pant MC. A report on the effect of Ocimum sanctum (Tulsi) leaves and seeds on blood and urinary uric acid, urea and urine volume in normal albino rabbits. Indian J Physiol Pharmacology 1990; 34: 6162.
10. Ravindran, R., Devi, R. S., Samson, J., & Senthilvelan, M. (2005). Noise-stress-induced brain neurotransmitter changes and the effect of Ocimum sanctum (Linn) treatment in albino rats. Journal of pharmacological sciences, 98(4), 354-360.
11. Khanna, N., & Bhatia, J. (2003). Antinociceptive action of Ocimum sanctum (Tulsi) in mice: possible mechanisms involved. Journal of ethnopharmacology, 88(2), 293-296.
12. Singh, S., & Majumdar, D. K. (1996). Effect of fixed oil of Ocimum sanctum against experimentally induced arthritis and joint edema in laboratory animals. Pharmaceutical Biology, 34(3), 218-222.
13. Nangia‐Makker, P., Tait, L., Shekhar, M. P., Palomino, E., Hogan, V., Piechocki, M. P., ... & Raz, A. (2007). Inhibition of breast tumor growth and angiogenesis by a medicinal herb: Ocimum gratissimum. International Journal of Cancer, 121(4), 884-894.
14. Singh, N., Verma, P., Pandey, B. R., & Bhalla, M. (2012). Therapeutic potential of Ocimum sanctum in prevention and treatment of cancer and exposure to radiation: An overview. International Journal of pharmaceutical sciences and drug research, 4(2), 97-104.
15. Chattopadhyay, R. R., Sarkar, S. K., Ganguly, S., Medda, C., & Basu, T. K. (1992). Hepatoprotective activity of Ocimum sanctum leaf extract against paracetamol induced hepatic damage in rats. Indian Journal of Pharmacology, 24(3), 163.
16. Kath, R. K., & Gupta, R. K. (2006). Antioxidant activity of hydroalcoholic leaf extract of Ocimum sanctum in animal models of peptic ulcer. Indian journal of physiology and pharmacology, 50(4), 391.
17. Devi, P. U., & Ganasoundari, A. (1999). Modulation of glutathione and antioxidant enzymes by Ocimum sanctum and its role in protection against radiation injury. Indian J Exp Biol, 37(3), 262-268.
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